US Patent #6630507
US Patent #6630507
Engineering is the art of making what you want from what you can get at a profit.
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paperburn1
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Re: US Patent #6630507
OK according to this patent pot you get high from is not usefull as a drug treatment.MSimon wrote:http://www.google.com/patents/US6630507
" Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention."
So once again more proof that as long as your not smoking and toking there is a possible benefit. As posted earlier there are plants out there with the same medicinal quality that do not contain the psychoactive cannabinoids that could be used for health care purposes.
But grow your own to self medicate is not legal, just like growing your own poppy seed / opiates is not legal.
somehow I do not feel that you want to differentiate between the "get you high" stuff and the "useful plant stuff"
as designated in the patent psychoactive elements are excluded
7. The method of claim 2, wherein the cannabinoid is:
where
A is cyclohexyl, substituted or unsubstituted aryl, or
but not a pinene;
R1 is H, substituted or unsubstituted alkyl, or substituted or unsubstituted carboxyl;
R2 is H, lower substituted or unsubstituted alkyl, or alkoxy;
R3 is of H, lower substituted or unsubstituted alkyl, or substituted or unsubstituted carboxyl;
R4 is H, hydroxyl, or lower substituted or unsubstituted alkyl; and
R5 is H, hydroxyl, or lower substituted or unsubstituted alkyl.
I am not a nuclear physicist, but play one on the internet.
Re: US Patent #6630507
Well actually it varies with the problem.paperburn1 wrote:OK according to this patent pot you get high from is not usefull as a drug treatment.MSimon wrote:http://www.google.com/patents/US6630507
" Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention."
So once again more proof that as long as your not smoking and toking there is a possible benefit. As posted earlier there are plants out there with the same medicinal quality that do not contain the psychoactive cannabinoids that could be used for health care purposes.
But grow your own to self medicate is not legal, just like growing your own poppy seed / opiates is not legal.
somehow I do not feel that you want to differentiate between the "get you high" stuff and the "useful plant stuff"
as designated in the patent psychoactive elements are excluded
7. The method of claim 2, wherein the cannabinoid is:
where
A is cyclohexyl, substituted or unsubstituted aryl, or
but not a pinene;
R1 is H, substituted or unsubstituted alkyl, or substituted or unsubstituted carboxyl;
R2 is H, lower substituted or unsubstituted alkyl, or alkoxy;
R3 is of H, lower substituted or unsubstituted alkyl, or substituted or unsubstituted carboxyl;
R4 is H, hydroxyl, or lower substituted or unsubstituted alkyl; and
R5 is H, hydroxyl, or lower substituted or unsubstituted alkyl.
Watch the videos here: http://classicalvalues.com/2013/02/cbd- ... -analysis/
The particular set of CBDs you want depends on the conditions being treated. We might know more if the stuff wasn't illegal. For some conditions high THC may be warranted. That is discussed in the videos.
The point is that the whole plant - high or low THC is illegal. And yet one of the set of chemicals in the plant is a patented by the US government medicine. Which is unavailable. You have to ask yourself why?
Medical Marijuana prohibition is a crime against humanity and a violation of the religious precept - heal the sick.
And why shouldn't people get high with it? It is safer than alcohol.
Engineering is the art of making what you want from what you can get at a profit.
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paperburn1
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Re: US Patent #6630507
I don't think alcohol is very safe as well and in my personal experience those that smoke on a regular basis are not that pleasant to be around either. IMHOMSimon wrote:
Watch the videos here: http://classicalvalues.com/2013/02/cbd- ... -analysis/
The point is that the whole plant - high or low THC is illegal. And yet one of the set of chemicals in the plant is a patented by the US government medicine. Which is unavailable. You have to ask yourself why?
And why shouldn't people get high with it? It is safer than alcohol.
I am not a nuclear physicist, but play one on the internet.
Re: US Patent #6630507
This heart surgeon suggests eating it.paperburn1 wrote:I don't think alcohol is very safe as well and in my personal experience those that smoke on a regular basis are not that pleasant to be around either. IMHOMSimon wrote:
Watch the videos here: http://classicalvalues.com/2013/02/cbd- ... -analysis/
The point is that the whole plant - high or low THC is illegal. And yet one of the set of chemicals in the plant is a patented by the US government medicine. Which is unavailable. You have to ask yourself why?
And why shouldn't people get high with it? It is safer than alcohol.
http://classicalvalues.com/2013/03/a-he ... marijuana/
Lots of people don't like smoke of any kind. Lots do. The trouble with eating for the high is that the dose is hard to calibrate. People complain of that with Marinol. When cannabis is used medically the calibration of the dose is called 'titration'. There are devices called vaporizers that some medicinal users use to avoid the smoke.
Engineering is the art of making what you want from what you can get at a profit.
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paperburn1
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Re: US Patent #6630507
Still breaking the law and I do not do illegal drugs. Give me a call when that changes then we may talk but I doubt it. psychoactive That says it all. and its not the smoke that bothers me its the type of person that smokes is usually the caused of my disdain.MSimon wrote:
This heart surgeon suggests eating it.
http://classicalvalues.com/2013/03/a-he ... marijuana/
Lots of people don't like smoke of any kind. Lots do. The trouble with eating for the high is that the dose is hard to calibrate. People complain of that with Marinol. When cannabis is used medically the calibration of the dose is called 'titration'. There are devices called vaporizers that some medicinal users use to avoid the smoke.
I am not a nuclear physicist, but play one on the internet.
Re: US Patent #6630507
Well the Nazis had laws against Jews. In America we do it more broadly. We have them against the sick and dying. Not directly mind. Just against medicine they might need. And you wouldn't break the law to save a human? Even at the risk of your own life?paperburn1 wrote:Still breaking the law and I do not do illegal drugs. Give me a call when that changes then we may talk but I doubt it. psychoactive That says it all. and its not the smoke that bothers me its the type of person that smokes is usually the caused of my disdain.MSimon wrote:
This heart surgeon suggests eating it.
http://classicalvalues.com/2013/03/a-he ... marijuana/
Lots of people don't like smoke of any kind. Lots do. The trouble with eating for the high is that the dose is hard to calibrate. People complain of that with Marinol. When cannabis is used medically the calibration of the dose is called 'titration'. There are devices called vaporizers that some medicinal users use to avoid the smoke.
No. Don't tell me. I'm not interested. Just think about it. The government says cannabidiol is medicine. Cannabidiol does not get you high. But you don't like the medicine because of the kind of people who use it.
Well that just confirms - pot smokers are the Jews of our system.
As soon as I can get to a state where it is legal I intend to take up the habit. Just to give you another reason to dislike me. I stand with the Jews. BTW for medicinal purposes 70% to 80% of Americans stand with the Jews.
Dr. Raphael Mechoulam - a Jew - stands with the Jews. You should look him up on the 'net. He was the first to synthesize THC. BTW THC is a legal drug. It is called Marinol. But only lab made THC is legal. If you get it from a plant it is not. Complicated, no?
My former Rabbi http://classicalvalues.com/2013/02/rabbi-jeffrey-kahn/ stands with the sick and dying. And would you believe he has Federal authority to do it because he lives in DC. It is getting complicated isn't it?
How about Federal Marijuana patient Irvin Rosenfeld the US Government sends him a little over 1/2 pound a month. http://medicalmarijuana.procon.org/view ... nID=000257 More complications.
Me? Just as I would not have hesitated to fight the German Nazis, I would not hesitate to fight the Drug Nazis.
http://classicalvalues.com/2013/03/drug-nazis/
Do you see why I say "Medical Marijuana prohibition is a crime against humanity and a violation of the religious precept - heal the sick." ? Funny. In such a religious Christian country Jews are taking the lead in this. The Reforms came out in favor of Med Pot around 2003-4. They spent a year on it. The Orthodox are not so unified but a number of them run dispensaries in Med Pot states. The general view in the Jewish community is "heal the sick, Government be damned". I stand with the Jews.
"Rightful liberty is unobstructed action according to our will within limits drawn around us by the equal rights of others. I do not add 'within the limits of the law' because law is often but the tyrant's will, and always so when it violates the rights of the individual." -- Thomas Jefferson
And the rights? Broadly - "Life, Liberty, and the Pursuit of Happiness" - you may have heard of that before.
I mean to misbehave.
Engineering is the art of making what you want from what you can get at a profit.
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paperburn1
- Posts: 2488
- Joined: Fri Jun 19, 2009 5:53 am
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Re: US Patent #6630507
misbehave away! 
your tirade just proved my point. If i am not 100 percent with you I am a drug Nazi No middle ground .
If your cause is just you will prevail , time will tell. You remind me of a crusader who went to the holy land to free it but whose real motivations were just his own benefits and not truly the concern for others.
one of the basic tenets of living is the good of the many over the good of the few or the one. Tempered with compassion but never to the point the few's benefits outweighing the good of the common whole.
aim to misbehave, did you watch some firefly?
your tirade just proved my point. If i am not 100 percent with you I am a drug Nazi No middle ground . If your cause is just you will prevail , time will tell. You remind me of a crusader who went to the holy land to free it but whose real motivations were just his own benefits and not truly the concern for others.
one of the basic tenets of living is the good of the many over the good of the few or the one. Tempered with compassion but never to the point the few's benefits outweighing the good of the common whole.
aim to misbehave, did you watch some firefly?
I am not a nuclear physicist, but play one on the internet.
Re: US Patent #6630507
The stuff that gets you high may be a cancer cure:
Journal of the National Cancer Institute,
Vol. 55, No. 3, September 1975, pp.597-602
By A.E. Munson, L.S. Harris, M.A. Friedman, W.L. Dewey, and R.A. Carchman
Department of Pharmacology and the MCV/VCU Cancer Center, Medical College of Virginia, Virginia Commonwealth University. Richmond, Va. 23298
Supported by Public Health Service grant DA00490 from the National Institute on Drug Abuse, Health Services & Mental Health Administration; by a grant from the Alexander and Margaret Stewart Trust Fund; and by an institutional grant from the American Cancer Society.
Summary --- Lewis lung adenocarcinoma growth was retarded by the oral administration of delta-9-tetrahydrocannabinol, delta-8-tetrahydrocannabinol, and cannabinol (CBN), but not cannabidiol (CBD). Animals treated for 10 consecutive days with delta-9-THC, beginning the day after tumor implantation, demonstrated a dose-dependent action of retarded tumor growth. Mice treated for 20 consecutive days with delta-8-THC and CBN had reduced primary tumor size. CBD showed no inhibitory effect on tumor growth at 14, 21, or 28 days. Delta-9-THC, delta-8-THC, and CBN increased the mean survival time (36% at 100 mg/kg, 25% at 200 mg/kg, and 27% at 50 mg/kg;, respectively), whereas CBD did not. Delta-9-THC administered orally daily until death in doses of 50, 100, or 200 mg/kg did not increase the life-spans of (C57BL/6 X DBA/2) F (BDF) mice hosting the L1210 murine leukemia. However, delta-9-THC administered daily for 10 days significantly inhibited Friend leukemia virus-induced splenomegaly by 71% at 200 mg/kg as compared to 90.2% for actinomycin D. Experiments with bone marrow and isolated Lewis lung cells incubated in vitro with delta-8-THC and delta-9-THC showed a dose-dependent (10 -4 10 -7) inhibition (80-20%, respectively) of tritiated thymidine and 14C -uridine uptake into these cells. CBD was active only in high concentrations (10 -4). ----J Natl Cancer Inst 55: 597-602, 1975.
Investigations into the physiologic processes affected by the psychoactive constitutuents of marihuana [delta-9-tetrahydrocannabinol (delta-9-THC) and delta-8-tetrahydrocannabinol (delta-8-THC)] purified from Cannabis sativa are extensive (1). However, only recently have attempts been made to elucidate the biochemical basis for their cytotoxic or cytostatic activity. Leuchtenberger et al. (2) demonstrated that human lung cultures exposed to marihuana smoke showed alterations in DNA synthesis, with the appearance of anaphase bridges. Zimmerman and McClean (3), studying macromolecular synthesis in Tetrahymena, indicated that very low concentrations of delta-9-THC inhibited RNA, DNA, and protein synthesis and produced cytolysis. Stenchever et al. (4) showed an increase in the number of damaged or broken chromosomes in chronic users of marihuana. Delta-9-THC administered iv inhibited bone marrow leukopoieses (5), and Kolodny et al. (6) reported that marihuana ;may impair testosterone secretion and spermatogenesis. Furthermore, Nahas et al. (7) showed that in chronic marihuana users there is a decreased lymphocyte reactivity to mitogens as measured by thymidine uptake. These and other (8) observations suggest that marihuana (delta-9-THC) interferes with vital cell biochemical processes, though no definite mechanism has yet been established. A preliminary report from this laboratory (9) indicated that the ability of delta-9-THC to interfere with normal cell functions might prove efficacious against neoplasms. This report represents an effort to test various cannabinoids in several in vivo and in vitro tumor systems to determine the kinds of tumors that are sensitive to these compounds and reveal their possible biochemical sites of action(s).
Full report here:
http://www.drugpolicycentral.com/bot/pg ... p_1975.htm
Journal of the National Cancer Institute,
Vol. 55, No. 3, September 1975, pp.597-602
By A.E. Munson, L.S. Harris, M.A. Friedman, W.L. Dewey, and R.A. Carchman
Department of Pharmacology and the MCV/VCU Cancer Center, Medical College of Virginia, Virginia Commonwealth University. Richmond, Va. 23298
Supported by Public Health Service grant DA00490 from the National Institute on Drug Abuse, Health Services & Mental Health Administration; by a grant from the Alexander and Margaret Stewart Trust Fund; and by an institutional grant from the American Cancer Society.
Summary --- Lewis lung adenocarcinoma growth was retarded by the oral administration of delta-9-tetrahydrocannabinol, delta-8-tetrahydrocannabinol, and cannabinol (CBN), but not cannabidiol (CBD). Animals treated for 10 consecutive days with delta-9-THC, beginning the day after tumor implantation, demonstrated a dose-dependent action of retarded tumor growth. Mice treated for 20 consecutive days with delta-8-THC and CBN had reduced primary tumor size. CBD showed no inhibitory effect on tumor growth at 14, 21, or 28 days. Delta-9-THC, delta-8-THC, and CBN increased the mean survival time (36% at 100 mg/kg, 25% at 200 mg/kg, and 27% at 50 mg/kg;, respectively), whereas CBD did not. Delta-9-THC administered orally daily until death in doses of 50, 100, or 200 mg/kg did not increase the life-spans of (C57BL/6 X DBA/2) F (BDF) mice hosting the L1210 murine leukemia. However, delta-9-THC administered daily for 10 days significantly inhibited Friend leukemia virus-induced splenomegaly by 71% at 200 mg/kg as compared to 90.2% for actinomycin D. Experiments with bone marrow and isolated Lewis lung cells incubated in vitro with delta-8-THC and delta-9-THC showed a dose-dependent (10 -4 10 -7) inhibition (80-20%, respectively) of tritiated thymidine and 14C -uridine uptake into these cells. CBD was active only in high concentrations (10 -4). ----J Natl Cancer Inst 55: 597-602, 1975.
Investigations into the physiologic processes affected by the psychoactive constitutuents of marihuana [delta-9-tetrahydrocannabinol (delta-9-THC) and delta-8-tetrahydrocannabinol (delta-8-THC)] purified from Cannabis sativa are extensive (1). However, only recently have attempts been made to elucidate the biochemical basis for their cytotoxic or cytostatic activity. Leuchtenberger et al. (2) demonstrated that human lung cultures exposed to marihuana smoke showed alterations in DNA synthesis, with the appearance of anaphase bridges. Zimmerman and McClean (3), studying macromolecular synthesis in Tetrahymena, indicated that very low concentrations of delta-9-THC inhibited RNA, DNA, and protein synthesis and produced cytolysis. Stenchever et al. (4) showed an increase in the number of damaged or broken chromosomes in chronic users of marihuana. Delta-9-THC administered iv inhibited bone marrow leukopoieses (5), and Kolodny et al. (6) reported that marihuana ;may impair testosterone secretion and spermatogenesis. Furthermore, Nahas et al. (7) showed that in chronic marihuana users there is a decreased lymphocyte reactivity to mitogens as measured by thymidine uptake. These and other (8) observations suggest that marihuana (delta-9-THC) interferes with vital cell biochemical processes, though no definite mechanism has yet been established. A preliminary report from this laboratory (9) indicated that the ability of delta-9-THC to interfere with normal cell functions might prove efficacious against neoplasms. This report represents an effort to test various cannabinoids in several in vivo and in vitro tumor systems to determine the kinds of tumors that are sensitive to these compounds and reveal their possible biochemical sites of action(s).
Full report here:
http://www.drugpolicycentral.com/bot/pg ... p_1975.htm
Engineering is the art of making what you want from what you can get at a profit.
Re: US Patent #6630507
Nature Medicine 6, 313 - 319 (2000)
doi:10.1038/73171
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
Ismael Galve-Roperh1,3, Cristina Sánchez1,3, María Luisa Cortés2, Teresa Gómez del Pulgar1, Marta Izquierdo2 & Manuel Guzmán1
Abstract
delta9-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of delta9-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used. Experiments with two subclones of C6 glioma cells in culture showed that cannabinoids signal apoptosis by a pathway involving cannabinoid receptors, sustained ceramide accumulation and Raf1/extracellular signal-regulated kinase activation. These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas.
From: http://www.nature.com/nm/journal/v6/n3/ ... 0_313.html
Note: above edited by replacing delta symbol which does not render here with "delta".
So it looks like the stuff that gets you high has anti-tumor properties.
doi:10.1038/73171
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
Ismael Galve-Roperh1,3, Cristina Sánchez1,3, María Luisa Cortés2, Teresa Gómez del Pulgar1, Marta Izquierdo2 & Manuel Guzmán1
Abstract
delta9-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of delta9-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used. Experiments with two subclones of C6 glioma cells in culture showed that cannabinoids signal apoptosis by a pathway involving cannabinoid receptors, sustained ceramide accumulation and Raf1/extracellular signal-regulated kinase activation. These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas.
From: http://www.nature.com/nm/journal/v6/n3/ ... 0_313.html
Note: above edited by replacing delta symbol which does not render here with "delta".
So it looks like the stuff that gets you high has anti-tumor properties.
Engineering is the art of making what you want from what you can get at a profit.
Re: US Patent #6630507
So letting people die because of your political convictions is OK? Just following orders then?paperburn1 wrote:misbehave away! :wink: your tirade just proved my point. If i am not 100 percent with you I am a drug Nazi No middle ground .
If your cause is just you will prevail , time will tell. You remind me of a crusader who went to the holy land to free it but whose real motivations were just his own benefits and not truly the concern for others.
one of the basic tenets of living is the good of the many over the good of the few or the one. Tempered with compassion but never to the point the few's benefits outweighing the good of the common whole.
aim to misbehave, did you watch some firefly?
No. I did not watch firefly. I picked it up from some one who did.
One of the tenets of Liberty is the rights of the individual. You know that your promotion of the many over the few is central to all forms of socialism. The collective you champion is central to communism. And currently the right in America is just as socialist as the left. Just about different things. My aim is to destroy socialism/collectivism in all its forms and restore Liberty.
And what are the rights of the individual according to our founding? Life, Liberty, and the Pursuit of Happiness.
Wish me Luck or to Hell. Either way my mind is made up. So far luck is with me.
18 Medical Cannabis States: http://medicalmarijuana.procon.org/view ... eID=000881
11 States Pending http://medicalmarijuana.procon.org/view ... eID=002481
And of course Washington and Colorado. What does that mean for the GOP? Losses, because the core of the GOP (like the core of the Democrats - except on this issue) is anti-Liberty. Collectivist to the bone. However a new generation is replacing the old. A pro-Liberty generation. My Generation
Engineering is the art of making what you want from what you can get at a profit.
Re: US Patent #6630507
But OK. Suppose we go with the greatest good for the greatest number. In America that means unequivocal support for med-pot. In the 70% to 80% range.
And legalization? http://www.rasmussenreports.com/public_ ... _marijuana - 56% support - but it currently varies from 48% to 58% depending on the poll.
So why aren't you on board with supporting the greatest good for the greatest number according to the people involved?
What? You mean that the people don't get to decide what is in their interest? That we are done with representative government?
Eventually we will have a national referendum (Presidential election) on the issue. Might be the election of 2016. Might be the election of 2020. When that happens the Right will get another 1932. Every two years the right loses 3.5 Million. What that means is that support for Prohibition declines by about 1.5 million every 2 years. 3 million every 4 years. How long will it take for electoral catastrophe to overtake your position? Not soon enough for my taste. But not long in the grand scheme of things.
Prohibitions have a typical lifetime of 50 years. If we count from Nixon's War on drugs that means it will be over by 2021. I'd say 2020 is close enough. Not more than 8 years from now. Maybe as soon as 4.
And legalization? http://www.rasmussenreports.com/public_ ... _marijuana - 56% support - but it currently varies from 48% to 58% depending on the poll.
So why aren't you on board with supporting the greatest good for the greatest number according to the people involved?
What? You mean that the people don't get to decide what is in their interest? That we are done with representative government?
Eventually we will have a national referendum (Presidential election) on the issue. Might be the election of 2016. Might be the election of 2020. When that happens the Right will get another 1932. Every two years the right loses 3.5 Million. What that means is that support for Prohibition declines by about 1.5 million every 2 years. 3 million every 4 years. How long will it take for electoral catastrophe to overtake your position? Not soon enough for my taste. But not long in the grand scheme of things.
Prohibitions have a typical lifetime of 50 years. If we count from Nixon's War on drugs that means it will be over by 2021. I'd say 2020 is close enough. Not more than 8 years from now. Maybe as soon as 4.
Engineering is the art of making what you want from what you can get at a profit.