Japan: Cannabis Can Prevent Tobacco Induced Cancer
Posted: Wed Aug 21, 2013 1:28 am
https://www.jstage.jst.go.jp/article/bp ... 3/_article
Cannabidiol (CBD), one of the major constituents in marijuana, 1) is not psychoactive but has several pharmacological effects such as prolonging drug-induced sleep, antiepileptic, anxiolytic, and antiemetic actions. 2) CBD is also known to inhibit hepatic microsomal drug metabolism in mammals. 3–5) A previous clinical study has shown that the administration of CBD reduces the systemic clearance of hexobarbital, which is metabolized by cytochrome P450 2C9 (CYP2C9), in human subjects.
6) In vitro studies by Jaeger et al. 7) and us 8–13) demonstrated that CBD inhibits catalytic activities of CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in human liver microsomes and/or recombinant CYP enzymes. Interestingly, we have recently reported that the CBD-mediated direct inhibition of human CYP1A1 activity is the strongest among those of CYP activities reported so far. 8) In addition, CYP1A1 was more potently inhibited by CBD than by the other major phytocannabinoids examined. 8)
Translation from the technical here:
http://www.theweedblog.com/cannabis-can ... new-study/
Medical Marijuana prohibition is a crime against humanity and a violation of the religious precept - heal the sick.
The Republican Party is going to get a great anti-science reputation from its opposition to Cannabis and especially medical cannabis. Way to go guys. The Democrats have a plan to exploit this in 2016. With a warm up in 2014.
Republicans stupid? Well of course.
Cannabidiol (CBD), one of the major constituents in marijuana, 1) is not psychoactive but has several pharmacological effects such as prolonging drug-induced sleep, antiepileptic, anxiolytic, and antiemetic actions. 2) CBD is also known to inhibit hepatic microsomal drug metabolism in mammals. 3–5) A previous clinical study has shown that the administration of CBD reduces the systemic clearance of hexobarbital, which is metabolized by cytochrome P450 2C9 (CYP2C9), in human subjects.
6) In vitro studies by Jaeger et al. 7) and us 8–13) demonstrated that CBD inhibits catalytic activities of CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in human liver microsomes and/or recombinant CYP enzymes. Interestingly, we have recently reported that the CBD-mediated direct inhibition of human CYP1A1 activity is the strongest among those of CYP activities reported so far. 8) In addition, CYP1A1 was more potently inhibited by CBD than by the other major phytocannabinoids examined. 8)
Translation from the technical here:
http://www.theweedblog.com/cannabis-can ... new-study/
Medical Marijuana prohibition is a crime against humanity and a violation of the religious precept - heal the sick.
The Republican Party is going to get a great anti-science reputation from its opposition to Cannabis and especially medical cannabis. Way to go guys. The Democrats have a plan to exploit this in 2016. With a warm up in 2014.
Republicans stupid? Well of course.