Talk-Polywell.org

From: http://www.world-science.net/exclusives ... ijuana.htm

The ac­tive com­pound res­pon­si­ble for ma­ri­jua­na’s “high” is called del­ta nine te­t­ra­hy­dro­can­na­bi­nol, or THC. This and re­lat­ed com­pounds, in high doses, tend to re­strict the re­lease of a chem­i­cal called glu­ta­mate from brain cells, Sarne and col­leagues ar­gued. This ef­fect can be help­ful be­cause ex­cess re­lease of glu­ta­mate—which is also an es­sen­tial chem­i­cal mes­sen­ger in the brain—is im­pli­cat­ed in var­i­ous dis­or­ders, in­clud­ing Alzheimer’s.

This, the scientists wrote, may ex­plain why THC-like com­pounds, called can­nabi­noids, help pro­tect brain cells in cases such as is­che­mia, or blocked blood ves­sels; ex­ci­to­tox­i­ci­ty, or over­sti­m­u­la­tion of nerve cells; and even phy­si­cal in­jur­ies.

Stud­ies sug­gest cannabi­noids tem­per glu­ta­mate re­lease by par­tially block­ing mo­lec­u­lar gate­ways in nerve cells, known as voltage-dependent cal­ci­um chan­nels, Sarne and col­leagues wrote.

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rcain wrote:From: http://medicalxpress.com/news/2012-07-n ... -pain.html

The discovery, detailed in a study led by neuroscience professor Paul Worley, M.D., of the Johns Hopkins University School of Medicine, focuses on a family of proteins called group 1 metabotropic glutamate receptors (mGluRs) that lie on the surfaces of nerve cells. When these receptors lock in glutamate, a chemical that neurons use to communicate, it encourages neurons to fire. Without a way to turn off these receptors, neurons would remain active indefinitely, keeping pain and other responses going long after they're useful. Previous research suggested that these mGluRs need to bind to another protein called Homer to shut down, and that this binding is stronger after other molecules called protein kinases modify the receptors. However, Worley explains, thus far it's been unclear exactly how all these different players come together. Seeking the mechanism behind this phenomenon, Worley and his colleagues started with a series of experiments to see what other proteins the mGluRs and Homer were binding with in rat brains. Their search turned up a third protein called Preso1, which bound to both mGluRs and Homer. A search in genetic databases shows that the gene responsible for making Preso1 is present in animals ranging from fruit flies to people, highlighting its importance in a wide variety of creatures.

ZYP

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