The Biology of Aging

[MSimon]

http://www.uccs.edu/rmelamed/biology-of-aging.html

[kurt9]

Aubrey tells me that recent research they've done has ruled out nuclear DNA damage as a cause of aging. Epigenetics (which is really DNA Methylation) is being researched at this time. The current debate is whether the primary cause is mitochondrial DNA damage (not the mitochondria themselves, since they are continually recycled) or telomere shortening. We know telomere shortening is associated with aging, whether its a cause or just a biomarker has yet to be determined.

There is recent research that suggested a link between mitochondrial DNA damage and how it results in telomere shortening in key stem cell populations in the human body.

In any case, there are both for-profit companies as well as non-profit research groups targeting both approaches to curing aging.

[Diogenes]

Aubrey tells me that recent research they've done has ruled out nuclear DNA damage as a cause of aging. Epigenetics (which is really DNA Methylation) is being researched at this time. The current debate is whether the primary cause is mitochondrial DNA damage (not the mitochondria themselves, since they are continually recycled) or telomere shortening. We know telomere shortening is associated with aging, whether its a cause or just a biomarker has yet to be determined.

There is recent research that suggested a link between mitochondrial DNA damage and how it results in telomere shortening in key stem cell populations in the human body.

In any case, there are both for-profit companies as well as non-profit research groups targeting both approaches to curing aging.

http://medicalxpress.com/news/2013-12-a ... ersed.html

[kurt9]

This is Sinclair again. Given his debacle with Resveratrol and the SIRT1 pathway, I would take this research with a grain of salt.

[ladajo]

I did not follow the link, but is that the mouse muscle regen thing that was making the rounds a few weeks or a month ago?

Or something else?