Factor X have we finally found the fountain of Youth?

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Diogenes
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Re: Factor X have we finally found the fountain of Youth?

Postby Diogenes » Wed Dec 06, 2017 1:29 am

paperburn1 wrote:But this ability will no doubt stifle creativity and the formation of new ideas making societies stagnate. We are experiencing this right now as demonstrated by our lawmakers and ultra wealthy that are only living a few more years than average. Rather than leap forwards to new venues and concepts they prefer to try and Keep the status quo. On a day to day basis you can currently pick out examples of people trying the same old ideas that keep the existing power structures and ideas in place. From our newest lawmaker ruling on taxes to social reform that is trying to mimic the "good old days" . A viable society is not build from the head down but from the feet up. Any group that does not conform to changes around it is doomed to fail as exhibited by history time and time again. Evolution is harsh for a reason and perhaps this is the true answer to Fermi paradox without death there is not enough motivation to take risks, and without that risky behavior it ultimately lead to society's collapse as no new solution are Implemented. Name me one great innovation or discover that was made without risk.
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Individuals mostly do not care about evolutionary scale. They care about themselves. This is going to happen, whether it be good for society or not.
‘What all the wise men promised has not happened, and what all the damned fools said would happen has come to pass.’
— Lord Melbourne —

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Tue Jan 09, 2018 6:24 am

RAADfest Sparks First Telomerase Clinical Trial: Hear Dr. Bill Andrews and James Strole


Published on Dec 14, 2017


James Strole, Director of the Coalition for Radical Life Extension, organizer of RAADfest, and Dr. Bill Andrews President of Sierra Sciences, speak on first ever Telomerase human trial targeting Alzheimer’s and aging.

Learn more about the study: http://www.libellagenetherapeutics.com/

Be all in for life. Register for RAADfest 2018 today: http://www.raadfest.com/

Learn more about the Coalition: http://www.rlecoalition.com/

The Coalition for Radical Life Extension is a non-profit organization.



He (Bill Andrews) says the first human subjects are expected to be treated around mid this year; the results he doesn't know how long it will take for them to show up afterwards.








https://www.youtube.com/watch?v=tVC4WmHg0w0

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Thu May 10, 2018 12:35 am

A stealthy Harvard startup wants to reverse aging in dogs, and humans could be next


Biologist George Church says the idea is to live to 130 in the body of a 22-year-old.

by Antonio Regalado May 9, 2018



The world’s most influential synthetic biologist is behind a new company that plans to rejuvenate dogs using gene therapy. If it works, he plans to try the same approach in people, and he might be one of the first volunteers.

The stealth startup Rejuvenate Bio, cofounded by George Church of Harvard Medical School, thinks dogs aren’t just man’s best friend but also the best way to bring age-defeating treatments to market.



The company, which has carried out preliminary tests on beagles, claims it will make animals “younger" by adding new DNA instructions to their bodies.

Its age-reversal plans build on tantalizing clues seen in simple organisms like worms and flies. Tweaking their genes can increase their life spans by double or better. Other research has shown that giving old mice blood transfusions from young ones can restore some biomarkers to youthful levels.



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Harvard biologist George Church is working on technology to reverse aging in dogs and humans.
Edge Foundation


“We have already done a bunch of trials in mice and we are doing some in dogs, and then we’ll move on to humans,” Church told the podcaster Rob Reid earlier this year. The company’s other founders, CEO Daniel Oliver and science lead Noah Davidsohn, a postdoc in Church’s sprawling Boston lab, declined to be interviewed for this article.

The company’s efforts to keep its activities out of the press make it unclear how many dogs it has treated so far. In a document provided by a West Coast veterinarian, dated last June, Rejuvenate said its gene therapy had been tested on four beagles with Tufts Veterinary School in Boston. It is unclear whether wider tests are under way.

However, from public documents, a patent application filed by Harvard, interviews with investors and dog breeders, and public comments made by the founders, MIT Technology Review assembled a portrait of a life-extension startup pursuing a longevity long shot through the $72-billion-a-year US pet industry.

“Dogs are a market in and of themselves,” Church said during an event in Boston last week. “It’s not just a big organism close to humans. It’s something people will pay for, and the FDA process is much faster. We’ll do dog trials, and that’ll be a product, and that’ll pay for scaling up in human trials.”

Image
Noah Davidsohn (left) and Daniel Oliver (right)—seen here with the dog-show announcer David Frei—have appealed to dog owners to fund an anti-aging study in pets.

It’s still unknown if the company’s treatments do anything for dogs. If they do work, however, it might not take long for people to clamor for similar nostrums, creating riches for inventors.

The effort draws on ongoing advances in biotechnology, including the ability to edit genes. To some scientists, this progress means that mastery over aging is inevitable, although no one can say exactly how soon it will happen. The prolongation of human lifespan is “the biggest thing that is going to happen in the 21st century,” says David Sinclair, a Harvard biologist who collaborates with the Church lab. “It’s going to make what Elon Musk is doing look fairly pedestrian.”

Dog years

Rejuvenate Bio has met with investors and won a grant from the US Special Operations Command to look into “enhancement” of military dogs while Harvard is seeking a broad patent on genetic means of aging control in species including the “cow, pig, horse, cat, dog, rat, etc.”

The team hit on the idea of treating pets because proving that it’s possible to increase longevity in humans would take too long. “You don’t want to go to the FDA and say we extend life by 20 years. They’d say, ‘Great, come back in 20 years with the data,’” Church said during the event in Boston.


Instead, Rejuvenate will first try to stop fatal heart ailments common in spaniels and Doberman pinschers, amassing evidence that the concepts can work in humans too.

Lab research already provides hints that aging can be reversed. For instance, scientists can “reprogram” any cell to take on the type of youthful state seen in an embryo. But turning back the aging program in animals is not as easy because we’re made up of trillions of specialized cells acting in concert, not just one floating in a dish. “I don’t think we are even near to being able to reverse the aging process as a whole in mammals,” says J. Pedro de Magalhães, whose team at the University of Liverpool maintains a database of longevity-connected genes.

Starting around 2015, Church’s large Harvard lab, also known for attempting to genetically resurrect the woolly mammoth, decided to make a run at rejuvenating mice using gene therapy and newer tools like CRISPR.

Gene therapies work by inserting DNA instructions into a virus, which conveys them into an animal’s cells. In the Harvard lab, the technology has been used to modulate gene activity in old mice—either increasing or lowering it—in an effort to return certain molecules to levels seen in younger, healthy animals.

Image
A flyer promoting a gene-therapy study in pet dogs says technology can make them “younger.”
Rejuvenate Bio


The lab started working through a pipeline of more than 60 different gene therapies, which it is testing on old mice, alone and in combinations. The Harvard group now plans to publish a scientific report on a technique that extends rodents’ lives by modifying two genes to act on four major diseases of aging: heart and kidney failure, obesity, and diabetes. According to Church, the results are “pretty eye-popping.”

Any age you want

In a January presentation about his project at Harvard, Davidsohn closed by displaying a picture of a white-bearded Church as he is now and another as he was decades ago, hair still auburn. Yet the second image was labelled 2117 AD—100 years in the future.

The images reflect Church’s aspirations for true age reversal. He says he’d sign up if a treatment proved safe, or even as a guinea pig in a study. Essentially, Church has said, the objective is to “have the body and mind of a 22-year-old but the experience of a 130-year-old.”

Such ideas are finding an audience in Silicon Valley, where billionaires like Peter Thiel look upon the defeat of aging as both a personal imperative and, potentially, a huge business that would transform society. Earlier this year, for example, Davidsohn told Thiel’s Founders Fund that because scientists can already modify life spans of simpler organisms, it should be possible to do so with humans as well. He told the investors that one day “we’ll be able to control the biological clock and keep you whatever age you want.”

Old dogs, new tricks

The new company has been contacting dog breeders, ethicists, and veterinarians with its ideas for restoring youth and extending “maximal life span,” according to its documents. The strategy is to gain a foothold in the pet market—where Americans already lavish $20 billion a year on vet bills—“before moving on to humans.”

Starting last year, Rejuvenate Bio began reaching out to owners of toy dogs called Cavalier King Charles spaniels after saying it planned a gene therapy to treat a heart ailment, mitral valve disease, that kills about half of these tiny dogs by age 10.

Rejuvenate hasn’t publicly disclosed what its dog therapy involves, but it may mirror one treatment Davidsohn has given mice to stop heart damage. That involved using gene therapy to block a protein, TGF-beta, termed a “master switch” in the process by which heart valves scar, thicken, and become misshapen, the same process that afflicts the dogs.

This spring, Davidsohn and Oliver traveled to Chicago to the breed’s national show, where they were feted at an auction dinner that raised several thousand dollars for the trial. Spaniel breeder Patty Kanan says the research is “seriously meaningful to the American Cavalier King Charles Spaniel Club,” of which she is president.

In a flyer circulated to spaniel owners last year, Rejuvenate stated, without qualification, that the still untested treatment would make pets “healthier, happier, and younger.” But not all dog owners are impressed.

To Rod Russell, editor of the website CavalierHealth.org, the offer is “pure hype.” He says there is “absolutely no evidence” for a way to make dogs younger and that even for pets, experimental drugs can’t be said to work before a study is complete. “No one would be naïve enough to contribute money on a promise that this treatment will make their Cavaliers younger. Or would they?” he asks on his site.

Image
A Cavalier King Charles spaniel. The adorable breed is plagued by a genetic heart condition that scientists are trying to reverse


A further question: even if the treatment stops progressive heart disease, is it “age reversal” or merely a form of disease prevention? To Church, the answer lies in whether an old dog’s body can heal like that of a young one. In any case, he predicts, pet owners won’t worry about semantics “if the dog is jumping around wagging its tail.”

Dog ethics

One doesn’t have to wait for aging reversal in humans to see how life extension could create some ethical quandaries. Last September, Rejuvenate Bio’s founders traveled to New Haven for a roundtable discussion with philosophers and ethicists organized by Lisa Moses, a veterinarian affiliated with Harvard Medical School.

For instance, if dogs’ lives can be extended, more pets would outlive their owners and end up in shelters or euthanized. “I do worry about unintended consequences,” says Moses. “I would want to see that investigated before this goes much further.”

The pet dogs Rejuvenate wants to test gene therapy on also have fewer special ethical protections than those in research facilities. “Pets fall into a legal gray zone when it comes to experimenting on them,” she says. The power of life and death sits in their owner’s hands; people can choose to put an ailing animal out of its misery or, just as often, take extraordinary medical steps to save it, which Moses says “don’t always benefit the patient.”

Life-extension treatments based on genetic modification could also bring unexpected side effects, according to Matt Kaeberlein, a University of Washington researcher involved in a study called the Dog Aging Project, who has been testing whether a drug called rapamycin causes dogs to live longer.

“The idea that we can genetically engineer lab animals to have longer life span has been validated. But there are concerns about bringing it out of the lab,” Kaeberlein says. “There are trade-offs.” Changing a gene that damages the heart could have other effects on dogs, perhaps making them less healthy in other ways. “And when you do these genetic modifications, there are many cases where it doesn’t work as you intend,” he adds. “What do you do with the dogs in which the treatment fails?”

Kaeberlein says he’d like to see stronger evidence of rejuvenation in mice before anyone tries it in a dog. Until then, he thinks, claims for youth-restoring medicine should be kept on a leash.

“They can talk about it all they want,but it hasn’t been done yet,” he says. “I think it’s good for getting people’s attention. But I am not sure it’s the most rigorous language in the world.”




https://www.technologyreview.com/s/6110 ... d-be-next/

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Mon Jul 23, 2018 12:29 pm

This is depressing, but probably not unexpected:

Liz Parrish and BioViva, a Chapter in the Telomerase Gene Therapy Book


It was the prelude to a breakup, a friendly (and perhaps temporary) parting of ways. In December 2017, a new company called Libella Gene Therapeutics announced that it had secured an exclusive license from Bill Andrews for his AAV Reverse (hTERT) transcriptase enzyme technology. Libella was now recruiting patients for a first-ever study in Cartagena, Colombia. There was no mention of BioViva, no mention of Parrish, no mention of her self-experiment.



As a part of efforts to push forward the treatment of aging as a medical condition, Liz Parrish underwent telomerase and follistatin gene therapies a few years ago. She formed a company, BioViva Sciences, to follow through. Self-experimentation is the most ethical of all possible ways proceed from animal studies to human studies, and is unfairly slandered in this day and age. There is a long history of notable researchers first testing their work on themselves. Self-experimentation must be followed through by success in business, fundraising, research and development, however - the areas in which all too many initiatives fail. The success rate of young companies is low in every field of endeavor.

This lengthy article tells the tale of a bold step and a follow through that faltered for all of the usual prosaic reasons. Could it all have been done better? Of course. It is easy to say that in hindsight and from the outside for any company, including the successful ones. Could BioViva have succeeded from the given starting point with difference choices and different allies along the way? Probably. Again something that can be said for near any venture. Perhaps exactly the same set of steps will be accomplished a few years from now and that effort will spark and succeed - sometimes it is just a matter of timing and what the various development and venture communities are prepared to accept. What we might choose to say on this matter, it is unequivocally the case that people are suffering and dying in vast numbers due to this medical condition called aging, and too little is being done about it. We need a thousand, ten thousand such bold steps and attempts to follow through.


Quote:


The room at the clinic in Bogota was clean and spare. There was a bed and, on her right, an IV drip. Over a period that lasted well into the night, there would be more than 100 injections. The pace was agonizingly slow. "So you're saying this will still get to my organs, right?" she asked the doctor as he inserted a needle below her kneecap. It would, he assured her. It was after midnight when she got the last injection.

It was September 16, 2015, and a strange kind of medical history had been made: in an untested procedure that would have violated federal regulations in the U.S., Elizabeth Parrish, a healthy 44-year-old the founder of a small biotech startup called BioViva, had received what she believed was a more potent dose of gene therapy than any other person ever had. She did it to fight what she called the "disease" of aging. She was, in her own words, Patient Zero in the quest for radically increased longevity.

Testing BioViva's products first on herself, Parrish said, had been the only ethical choice. She hadn't turned back into a 25-year-old. Nor, on the bright side, did she appear to have cancer. Her biomarkers - triglycerides, C-reactive protein, muscle mass - were promising but ultimately inconclusive, since they were the results of just one person, and not published in a peer-reviewed study. The results of Parrish's telomere tests showed average length in white blood cells had increased by 9 percent. A press release said that this was equivalent to reversing 20 years of aging. But there was no published study to go along with it, and the news was easy to dismiss.

For two years, Parrish had been claiming that BioViva would soon open overseas clinics. Not long before RAADfest 2016, she and Bill Andrews of Sierra Sciences had made a coordinated announcement: they were partnering in a new venture called BioViva Fiji. They showed off an architectural rendering of a generically modern gene-therapy clinic. When the Fijian press caught wind of BioViva Fiji, authorities told journalists that it didn't exist, not even on paper. And at RAADfest 2017, neither Parrish nor Andrews seemed too keen to talk about it anymore.

It was the prelude to a breakup, a friendly (and perhaps temporary) parting of ways. In December 2017, a new company called Libella Gene Therapeutics announced that it had secured an exclusive license from Bill Andrews for his AAV Reverse (hTERT) transcriptase enzyme technology. Libella was now recruiting patients for a first-ever study in Cartagena, Colombia. There was no mention of BioViva, no mention of Parrish, no mention of her self-experiment.

Parrish and I met for lunch so she could tell me about BioViva's new direction. "So, BioViva is now a bioinformatics company!" she announced. It was pivoting. It wasn't trying to do clinical trials for the time being. Even offshore, away from the FDA, they cost millions of dollars, and raising that kind of money to do traditional trials would amount to the kind of slow-moving medicine she was trying to overcome. BioViva would be a data platform for other companies, collecting and analyzing the information they gathered from their trials.

https://www.outsideonline.com/2325556/l ... ve-forever









https://www.fightaging.org/archives/201 ... rapy-book/

kurt9
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Re: Factor X have we finally found the fountain of Youth?

Postby kurt9 » Sat Jul 28, 2018 5:24 pm

Reading between the lines on Liz Parrish's endeavor, I draw a different conclusion. Her therapy worked in the technical sense that it delivered the gene therapy into the cells that she wanted it to. However, all of the recent (post 2015 work) research suggests that teleomere shortening is not a cause of aging. I think Liz recognized this and decided to turn her company into a bio-informatics one as a result. I never really accepted the telomere shortening theory anyways, leaning more towards "SENS-like" explanations such as mtDNA damage.

What is significant about BioViva was that it was essentially a garage-level effort to develop genet therapies from scratch, and that it was successful on that level alone. I've been in biotech labs in Taiwan and other Asian countries. The small physical size and low capital cost of such is quite shocking! This is not like building billion dollar semiconductor fabs (which are also all over Asia). The capabilities of bio-engineering will only increase into the future, thus making garage -level efforts even more potent and significant. BioViva demonstrated that the age of DIY medicine has arrived even if its specific gene therapy does not cure aging. Such efforts will only grow more significant into the future.

The recent work (since 2016) is suggesting that aging is mainly due to mtDNA damage or some other form of mitochondrial dysfunction as well as immunosenescence, with the former causing the latter. Both of these mechanisms suggest that aging should really be curable through DIY medicine within the next 20 years. This is significant because it makes it easy to bypass all of the any-sayers. It is one thing for it to require a multi-billion dollar effort involving inputs from across the political spectrum. But if it is fundamentally cheap enough to develop on our own, we can just ignore the political debate and just f**king do it, just like the old Nike ad: "Just Do It".

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sat Jul 28, 2018 6:16 pm

kurt9 wrote:Reading between the lines on Liz Parrish's endeavor, I draw a different conclusion. Her therapy worked in the technical sense that it delivered the gene therapy into the cells that she wanted it to. However, all of the recent (post 2015 work) research suggests that teleomere shortening is not a cause of aging. I think Liz recognized this and decided to turn her company into a bio-informatics one as a result. I never really accepted the telomere shortening theory anyways, leaning more towards "SENS-like" explanations such as mtDNA damage.



You may be right...however Bill Andrews seemed to suggest in another video that he isn't sure that Parrish's methodology of inducing the telomerase therapy was quite right. That is he suggested that strongly and made clear he wasn't directly involved in her self experimentation, for whatever that is worth. The disheartening part is no mention made of what happened about the Fiji efforts allegedly happening last year or this Summer's supposed 2 million dollar telomerase treatment that was supposed to have happened about now and clearly isn't; at least not yet. Suggestive of more than a whiff of snake oil I am sorry to say but I hope not.

kurt9 wrote:What is significant about BioViva was that it was essentially a garage-level effort to develop genet therapies from scratch, and that it was successful on that level alone. I've been in biotech labs in Taiwan and other Asian countries. The small physical size and low capital cost of such is quite shocking! This is not like building billion dollar semiconductor fabs (which are also all over Asia). The capabilities of bio-engineering will only increase into the future, thus making garage -level efforts even more potent and significant. BioViva demonstrated that the age of DIY medicine has arrived even if its specific gene therapy does not cure aging. Such efforts will only grow more significant into the future.


If it really is "garage-level" then we should expect to see some rejuvenated dogs in the not to distant future; easier to get approval and a stand alone paying business. Some rich person paying to have their beloved "fifi" made young again.

kurt9 wrote:The recent work (since 2016) is suggesting that aging is mainly due to mtDNA damage or some other form of mitochondrial dysfunction as well as immunosenescence, with the former causing the latter. Both of these mechanisms suggest that aging should really be curable through DIY medicine within the next 20 years.


Feel free to post any links here that show such and especially debunk the telomere shortening theory of aging. At face value it seems reasonable to me; since we have known about the "Hayflick limit" for 50 years, hard to believe the fact that your cells stop dividing/replacing senescent cells doesn't have a major impact on somatic aging. Though obviously other things effect aging like oxidative stress caused by free radicals.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Wed Aug 01, 2018 1:30 pm

A World with Successful Reversal of Aging will first see twenty year old mice and young Stallone

George Church has stated that the scientific results of the mice gene aging reversal work is eye-popping. It has also been stated that the dog aging reversal work has already started. George Church has indicated that he will be among the first humans to trial the aging reversal procedures.



Image

When will we know that antiaging rejuvenation using damage and age reserval really works? In such a world we will see 20 year old mice and a young Sylvester Stallone. Stallone is a wealthy famous person who uses human growth hormone and other treatments to stay youthful. George Church is a scientist deeply involved in founding and running many companies developing antiaging.

This is the standard for the robust mouse rejuvenation program. Aubrey de Grey believes that about 15 years after the robustly rejuvenated mouse there will be multiple rejuvenations of the same mice and many could have combinations of aging reversal treatments.

The aging reversal work of Rejuvenate Bio and the removal of accumulated aging cells from Oisin Biotechnology are treatments that can and will need to be re-applied every year or so.


Image


Image


Image

There was a presentation about multiple reversal of aging damage treatments.

The gene therapy that is being used are injections of DNA plasmids (for changing genes) encased in lipid spheres. Re-application will be like an immunization booster shot. They have tracked the material spreading throughout the body of adult mice. This means there are delivery mechanisms for whole body wide genetic modification.

If one powerful combination of rejuvenation could enable mice that live to 5-years of age, then if those reversal of aging damage treatments could work three to four times then we could see 8-year old mice. The number of reversal of aging treatments and tests would rapidly expand with the first robust mouse rejuvenation. If it took 15 years for the reversal of aging treatments to be applied in humans then the multiply rejuvenated mice would have reached about 20 years of age.

Recent research suggests we could be near to have two-year-old mice reach 5-year lifespans.

Oisin Biotechnology is a leader in removing senescent cells for antiaging. They have injected a combination of two gene therapies into mice. The two-year-old mice would normally live to 3 years of age. Instead of only 50% surviving to 2.5, there are 90% of the treated mice living to 2.5 years with single treatment. Perhaps 80% could live to 3 and 50% could live to 4.



Image


There is more reversal of aging tests with Rejuvenate Bio on mice and dogs. The research has not been published yet but they are working on 60 gene therapies to reverse different aspects of aging.

George Church has stated that the scientific results of the mice gene aging reversal work is eye-popping. It has also been stated that the dog aging reversal work has already started. George Church has indicated that he will be among the first humans to trial the aging reversal procedures.

What will the procedures be like for aging reversal

Successful rejuvenation needs to be repeated to continue to clear away the re-accumulated damage.

There will be regular injections of combination gene therapy treatments that clear away aging damage.

There is many billions of dollars in research to boost the t-cells of the immune system to fight cancer. There are many different kinds of cancer that are being targeted. Enhancing the immune system to fight cancer and replacing the immune system cells with rejuvenated cells will be another part of antiaging treatment.

There will injections of rejuvenated immune system cells.

If there is successful development of full human regeneration from the companies AgeX and Biotime, then the number of anti-aging injections could be reduced.


https://www.nextbigfuture.com/2018/07/a ... llone.html

paperburn1
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Re: Factor X have we finally found the fountain of Youth?

Postby paperburn1 » Fri Aug 03, 2018 9:58 pm

May not be immortality but its a start
https://www.bbc.com/news/science-environment-45046674
Then, they regenerated the lung over 30 days in a piece of equipment called a bioreactor, using cells from the eventual recipient of the lung. A bioreactor is a machine that supports the development of biological tissue. If the recipient animal's cells are used, it reduces the likelihood that the pig's immune system will reject a transplanted organ because it recognises the tissue as its own.
I am not a nuclear physicist, but play one on the internet.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sat Aug 04, 2018 1:06 pm

paperburn1 wrote:May not be immortality but its a start


Actually even assuming the above posted "longevity treatments" causing age reversal posted above it seems to me you would still need the ability to grow new organs/tissues. After all what about accidents/injuries? With a much longer life expectancy created by the treatments you now have statistically a higher probability of suffering some kind of severe traumatic injury. Think of for example fatal car accidents; about 30K a year die in the United States alone on average even with seatbelts, airbags and such. A larger set suffering serious if not fatal accidents requiring significant repair/rehab. The odds of you suffering such a traumatic injury go way up if you start living 2-5X times longer than we do now even with very likely improvements in safety; i.e. self-driving cars. To say nothing of the risks of an "adventure vacation" via Musk's BFR to among other places the "Lunar pleasure palace"; outside of any countries' legal jurisdiction, most anything goes come at your own risk. Alleviating boredom being perhaps one of the likely hazards of "immortality".

paperburn1
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Re: Factor X have we finally found the fountain of Youth?

Postby paperburn1 » Sat Aug 04, 2018 10:35 pm

your right, that's something I did not think about, given our current accidental death rate it would make you hard pressed to find someone 10,000 years old even if we lived forever. :shock:
I am not a nuclear physicist, but play one on the internet.

hanelyp
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Re: Factor X have we finally found the fountain of Youth?

Postby hanelyp » Sat Aug 04, 2018 11:04 pm

The number I came to looking at mortality figures several years ago, excluding old age and infant mortality, was an average lifespan around 1000 years. Of course both luck and lifestyle choice would impact that. Half the population would have a fatal accident sometime during their first 1000 years, half would meet or pass that mark. And so on for each half-life period. Neglecting impact of lifestyle on accident rate, ~1/1000 would reach 10,000 years of age.
The daylight is uncomfortably bright for eyes so long in the dark.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Aug 05, 2018 12:07 am

hanelyp wrote:The number I came to looking at mortality figures several years ago, excluding old age and infant mortality, was an average lifespan around 1000 years. Of course both luck and lifestyle choice would impact that. Half the population would have a fatal accident sometime during their first 1000 years, half would meet or pass that mark. And so on for each half-life period. Neglecting impact of lifestyle on accident rate, ~1/1000 would reach 10,000 years of age.


Does your theoretical mortality figures take into consideration death by other means than accidental? Homicide (or suicide) to say nothing of war? The odds of most of us living to see a large WWI or WWII sized dust up (or a smaller scale but multiple terrorist type) are greatly increased with a life span measuring centuries. To say nothing of a deliberately engineered global pandemic.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Aug 05, 2018 5:51 pm

Osin Biotechnologies could be on the verge of cancer and antiaging breakthroughs


Image


Clearing old “zombie” cells from the human body has been shown to extend the lives of mice.

When cells detect that they have been irreversibly damaged, they enter a non-dividing condition known as cell-cycle arrest, or senescence. It’s believed this occurs to prevent cells from going rogue and turning cancerous. Ideally, they should die by the process known as apoptosis, but as we age, more and more frequently they don’t. They become zombie cells – unable to kill themselves or resume normal function.

Senescent cells secrete molecules that cause inflammation in an effort to attract immune cells that would usually clear them. But for reasons that are not fully known, as we age, persistently senescent cells accumulate, leading to a vast number of age-related diseases.

Oisín is developing a highly precise, patent-pending, DNA-targeted intervention to clear these cells.

Osin Biotechnologies will start clinical trials testing senescent cell human trials should start in 2019 with the target of fighting cancer. These clinical trials will be to use repeated dosing of lipids with gene therapy to trigger cell death in cells that show P19 and other active genes.

Osin has been able to repeatedly and safely apply gene therapy safely throughout the bodies of mice and monkeys.

Repeated dosing has been shown to reduce tumor size and control certain cancers in mouse models. They have tested repeated dosing in monkeys as well.

The phase 1 and phase 2 clinical trials will hopefully prove that the repeated dosing is safe and effective in humans.

In Canada, Osin will be able to take cancer patients with any type of cancer. Osin will proceed to later phases against the cancers which respond best to their treatments.

Image

Image

Repeated dosing to achieve antiaging breakthrough 5-year old mice

In the antiaging trials on mice, 90% 2-year-old mice that received one dose of the combination treatment survived to 2.5 years while only 50% of untreated mice survived.

If repeated dosing was as effective as the first 6 months then 53% of the mice might survive to 5 years of age. (0.9*0.9*0.9*0.9*0.9*0.9 = 0.53). This would mean the Antiaging Mouse prize would be won. The optimal dosing schedule to keep senescent cells cleared might be even more frequent than once every 6 months in mice. It might be once every month or two.

Aubrey de Grey and SENS have talked about robust mouse rejuvenation being the key milestone for antiaging. By 2021, we could know if Osin Biotech can achieve it with repeated dosing of senescent cell clearing.




https://www.nextbigfuture.com/2018/08/o ... oughs.html

williatw
Posts: 1702
Joined: Mon Oct 12, 2009 7:15 pm
Location: Ohio

Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Aug 05, 2018 5:53 pm

John Lewis at Undoing Aging 2018


https://www.youtube.com/watch?v=frWklN81hz4

williatw
Posts: 1702
Joined: Mon Oct 12, 2009 7:15 pm
Location: Ohio

Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Mon Aug 06, 2018 8:22 am

Combining AgeX, Osin Biotech and Rejuvenate Bio for huge antiaging


Image

Osin is extending the life of mice and has proven safety and improvement in monkeys. They will start human clinical trials in 2019.


Rejuvenate Bio has 60 aging reversal gene therapies. They have mentioned but not yet published eye popping results in mice. They are testing aging reversal in dogs in 2018-2019. Human treatments could be available on a general basis by 2025.


Michael West explains his theory that the body normally gets rid of senescent cells when we are younger because the body has enough rejuvenation to replace the cells.

However, the older body cannot replace the cells as easily so the body says wait lets keep those heart cells or other cells because I cannot replace them.


Mike West at Undoing Aging 2018
https://www.youtube.com/watch?v=vaoP5lA0hps


AgeX is trying to use telomerase and induced regeneration to enable the body to constantly maintain regeneration. This could mean that the body would go back to aggressively getting rid of sub-standard cells.

By itself, AgeX might achieve massive human longevity gains.

If the body still did not get rid of the substandard cells then work at Osin Biotechnology and others would enable to bad cells to be cleared.

Osin is extending the life of mice and has proven safety and improvement in monkeys. They will start human clinical trials in 2019.


Rejuvenate Bio has 60 aging reversal gene therapies. They have mentioned but not yet published eye popping results in mice. They are testing aging reversal in dogs in 2018-2019. Human treatments could be available on a general basis by 2025.



https://www.nextbigfuture.com/2018/08/c ... aging.html

Don't know about you gentlemen (& ladies) but I am ready for "eye popping results"; any day now please.


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