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Betruger
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Postby Betruger » Tue Nov 11, 2008 5:37 pm


Skipjack
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Postby Skipjack » Tue Nov 11, 2008 5:49 pm


MSimon
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Postby MSimon » Tue Nov 11, 2008 5:51 pm


Mike Holmes
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Postby Mike Holmes » Tue Nov 11, 2008 8:00 pm

Last edited by Mike Holmes on Tue Nov 11, 2008 8:09 pm, edited 1 time in total.

Skipjack
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Postby Skipjack » Tue Nov 11, 2008 8:08 pm


Mike Holmes
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Postby Mike Holmes » Tue Nov 11, 2008 8:23 pm


MSimon
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Postby MSimon » Tue Nov 11, 2008 10:33 pm


MSimon
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Postby MSimon » Tue Nov 11, 2008 11:14 pm

And Skip,

Since I'm still in my nice guy mode here is a bit to give you some search terms to work with.

===

CB1

Main article: Cannabinoid receptor type 1

Cannabinoid receptor type 1 (CB1) receptors are thought to be the most widely expressed G-protein coupled receptors in the brain. This is due to endocannabinoid-mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized neuron bind to CB1 receptors in the pre-synaptic neuron and cause a reduction in GABA release.

They are also found in other parts of the body. For instance, in the liver, activation of the CB1 receptor is known to increase de novo lipogenesis,[6] Activation of presynaptic CB1 receptors is also known to inhibit sympathetic innervation of blood vessels and contributes to the suppression of the neurogenic vasopressor response in septic shock.[7]

CB2

Main article: CB2 receptor

CB2 receptors are mainly expressed on T cells of the immune system, on macrophages and B cells, and in hematopoietic cells. They also have a function in keratinocytes, and are expressed on mouse pre-implantation embryos. It is also expressed on peripheral nerve terminals.In the brain, they are mainly expressed by microglial cells, where their role remains unclear.

Other cannabinoid receptors

The existance of additional cannabinoid receptors has long been suspected, due to the actions of compounds such as abnormal cannabidiol which produce cannabinoid-like effects on blood pressure and inflammation, yet do not activate either CB1 or CB2.[8][9][10] Recent molecular biology research suggested that the orphan receptor GPR55 should in fact be characterised as a cannabinoid receptor, on the basis of sequence homology at the binding site. Subsequent studies showed that GPR55 does indeed respond to cannabinoid ligands.[11][12] This profile as a distinct non-CB1/CB2 receptor which responds to a variety of both endogenous and exogenous cannabinoid ligands, has led some groups to suggest GPR55 should be categorised as the CB3 receptor, and this re-classification may follow in time.[13] However this is complicated by the fact that another possible cannabinoid receptor has been discovered in the hippocampus, although its gene has not yet been cloned,[14] suggesting that there may be at least two more cannabinoid receptors to be discovered, in addition to the two that are already known.

From:

http://en.wikipedia.org/wiki/Cannabinoid_receptor

Betruger
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Postby Betruger » Wed Nov 12, 2008 12:11 am


MSimon
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Postby MSimon » Wed Nov 12, 2008 1:13 am


djolds1
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Postby djolds1 » Wed Nov 12, 2008 2:03 am

Vae Victis

olivier
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Postby olivier » Wed Nov 12, 2008 7:55 am

I happen to be reading a book which might prove helpful to both parties. I suggest that they read, if they haven't already, "The Art of Controversy" by Schopenhauer. For those who might be afraid of German philosophers, I guarantee it is short, easy to read, inexpensive and useful in many circumstances. A is available on the web. :)

rcain
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Postby rcain » Wed Nov 12, 2008 10:11 am

Drugs are fun aren't they :twisted:

excellent link there Olivier

i feel sure there must exist some flavor of 'Godwins' law relating to the probability of recreational chemical use being introduced (in some form) into forum discussions.

Betruger
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Postby Betruger » Wed Nov 12, 2008 12:45 pm

That's "The art of always being right", isn't it?
It is. Yep, good reference book, even if it's a bit repetitive sometimes.

olivier
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Postby olivier » Wed Nov 12, 2008 1:19 pm

Yes it is. "Always being right" is a better translation of the title. It is nearly 200 years old and still valid in the Internet age. I originally bought the book as a source of examples for my kids!


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