Factor X have we finally found the fountain of Youth?

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Diogenes
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Re: Factor X have we finally found the fountain of Youth?

Postby Diogenes » Wed Dec 06, 2017 1:29 am

‘What all the wise men promised has not happened, and what all the damned fools said would happen has come to pass.’
— Lord Melbourne —

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Tue Jan 09, 2018 6:24 am


williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Thu May 10, 2018 12:35 am


williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Mon Jul 23, 2018 12:29 pm


kurt9
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Re: Factor X have we finally found the fountain of Youth?

Postby kurt9 » Sat Jul 28, 2018 5:24 pm

Reading between the lines on Liz Parrish's endeavor, I draw a different conclusion. Her therapy worked in the technical sense that it delivered the gene therapy into the cells that she wanted it to. However, all of the recent (post 2015 work) research suggests that teleomere shortening is not a cause of aging. I think Liz recognized this and decided to turn her company into a bio-informatics one as a result. I never really accepted the telomere shortening theory anyways, leaning more towards "SENS-like" explanations such as mtDNA damage.

What is significant about BioViva was that it was essentially a garage-level effort to develop genet therapies from scratch, and that it was successful on that level alone. I've been in biotech labs in Taiwan and other Asian countries. The small physical size and low capital cost of such is quite shocking! This is not like building billion dollar semiconductor fabs (which are also all over Asia). The capabilities of bio-engineering will only increase into the future, thus making garage -level efforts even more potent and significant. BioViva demonstrated that the age of DIY medicine has arrived even if its specific gene therapy does not cure aging. Such efforts will only grow more significant into the future.

The recent work (since 2016) is suggesting that aging is mainly due to mtDNA damage or some other form of mitochondrial dysfunction as well as immunosenescence, with the former causing the latter. Both of these mechanisms suggest that aging should really be curable through DIY medicine within the next 20 years. This is significant because it makes it easy to bypass all of the any-sayers. It is one thing for it to require a multi-billion dollar effort involving inputs from across the political spectrum. But if it is fundamentally cheap enough to develop on our own, we can just ignore the political debate and just f**king do it, just like the old Nike ad: "Just Do It".

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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sat Jul 28, 2018 6:16 pm


williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Wed Aug 01, 2018 1:30 pm


paperburn1
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Re: Factor X have we finally found the fountain of Youth?

Postby paperburn1 » Fri Aug 03, 2018 9:58 pm

May not be immortality but its a start
https://www.bbc.com/news/science-environment-45046674
Then, they regenerated the lung over 30 days in a piece of equipment called a bioreactor, using cells from the eventual recipient of the lung. A bioreactor is a machine that supports the development of biological tissue. If the recipient animal's cells are used, it reduces the likelihood that the pig's immune system will reject a transplanted organ because it recognises the tissue as its own.
I am not a nuclear physicist, but play one on the internet.

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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sat Aug 04, 2018 1:06 pm


paperburn1
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Re: Factor X have we finally found the fountain of Youth?

Postby paperburn1 » Sat Aug 04, 2018 10:35 pm

your right, that's something I did not think about, given our current accidental death rate it would make you hard pressed to find someone 10,000 years old even if we lived forever. :shock:
I am not a nuclear physicist, but play one on the internet.

hanelyp
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Re: Factor X have we finally found the fountain of Youth?

Postby hanelyp » Sat Aug 04, 2018 11:04 pm

The number I came to looking at mortality figures several years ago, excluding old age and infant mortality, was an average lifespan around 1000 years. Of course both luck and lifestyle choice would impact that. Half the population would have a fatal accident sometime during their first 1000 years, half would meet or pass that mark. And so on for each half-life period. Neglecting impact of lifestyle on accident rate, ~1/1000 would reach 10,000 years of age.
The daylight is uncomfortably bright for eyes so long in the dark.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Aug 05, 2018 12:07 am


williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Aug 05, 2018 5:51 pm




Image


Clearing old “zombie” cells from the human body has been shown to extend the lives of mice.

When cells detect that they have been irreversibly damaged, they enter a non-dividing condition known as cell-cycle arrest, or senescence. It’s believed this occurs to prevent cells from going rogue and turning cancerous. Ideally, they should die by the process known as apoptosis, but as we age, more and more frequently they don’t. They become zombie cells – unable to kill themselves or resume normal function.

Senescent cells secrete molecules that cause inflammation in an effort to attract immune cells that would usually clear them. But for reasons that are not fully known, as we age, persistently senescent cells accumulate, leading to a vast number of age-related diseases.

Oisín is developing a highly precise, patent-pending, DNA-targeted intervention to clear these cells.

Osin Biotechnologies will start clinical trials testing senescent cell human trials should start in 2019 with the target of fighting cancer. These clinical trials will be to use repeated dosing of lipids with gene therapy to trigger cell death in cells that show P19 and other active genes.

Osin has been able to repeatedly and safely apply gene therapy safely throughout the bodies of mice and monkeys.

Repeated dosing has been shown to reduce tumor size and control certain cancers in mouse models. They have tested repeated dosing in monkeys as well.

The phase 1 and phase 2 clinical trials will hopefully prove that the repeated dosing is safe and effective in humans.

In Canada, Osin will be able to take cancer patients with any type of cancer. Osin will proceed to later phases against the cancers which respond best to their treatments.

Image

Image



In the antiaging trials on mice, 90% 2-year-old mice that received one dose of the combination treatment survived to 2.5 years while only 50% of untreated mice survived.

If repeated dosing was as effective as the first 6 months then 53% of the mice might survive to 5 years of age. (0.9*0.9*0.9*0.9*0.9*0.9 = 0.53). This would mean the Antiaging Mouse prize would be won. The optimal dosing schedule to keep senescent cells cleared might be even more frequent than once every 6 months in mice. It might be once every month or two.

Aubrey de Grey and SENS have talked about robust mouse rejuvenation being the key milestone for antiaging. By 2021, we could know if Osin Biotech can achieve it with repeated dosing of senescent cell clearing.




https://www.nextbigfuture.com/2018/08/o ... oughs.html

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Sun Aug 05, 2018 5:53 pm

John Lewis at Undoing Aging 2018


https://www.youtube.com/watch?v=frWklN81hz4

williatw
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Re: Factor X have we finally found the fountain of Youth?

Postby williatw » Mon Aug 06, 2018 8:22 am



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