Factor X have we finally found the fountain of Youth?

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Skipjack
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Post by Skipjack »

Nowadays, that is truer than ever. Democrat and Liberal are pretty much interchangeable.
Looking a the US politics of the past 12 years or so, I could say the same about "democrat and republican". In those matters where it really counts they have made pretty much the same decisions lately (and together).
NDAA, CISPA, SOPA, etc, etc all dreamed up by Dems and Reps together.

williatw
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Post by williatw »

Telomerase gene Therapy increase mouse lifespan by 24% without causing Cancer
http://nextbigfuture.com/2012/05/telome ... -mice.html

Diogenes
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Post by Diogenes »

Skipjack wrote:
Nowadays, that is truer than ever. Democrat and Liberal are pretty much interchangeable.
Looking a the US politics of the past 12 years or so, I could say the same about "democrat and republican". In those matters where it really counts they have made pretty much the same decisions lately (and together).
NDAA, CISPA, SOPA, etc, etc all dreamed up by Dems and Reps together.

It is an realization that is not lost on the Republican's base of support. There is substantial movement throughout the Republican base to kick out of office these unreliable Senators and Congressmen. We just knocked out Dick Lugar, and now we are going after Orrin Hatch.

It is time for them to go.


Klein: It's time for Hatch to go


Image



It's easy for Republicans to talk a big game about shrinking government when a Democrat is in the White House. A much better test of a lawmaker's commitment to limited-government principles is how he or she behaves when a Republican president is in office, pushing a big-government agenda.

As President Bush worked with Congressional Republicans to explode government when they were in power, Hatch voted with him every step of the way. He voted to expand the federal role in education with "No Child Left Behind" and for the biggest expansion of entitlements since LBJ's Great Society in the form of the Medicare prescription drug plan.

http://campaign2012.washingtonexaminer. ... -go/531731
‘What all the wise men promised has not happened, and what all the damned fools said would happen has come to pass.’
— Lord Melbourne —

williatw
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Re: Factor X have we finally found the fountain of Youth?

Post by williatw »

SENS anti-aging approach is winning the battle of ideas

http://nextbigfuture.com/2013/09/sens-a ... nning.html

Aubrey de Grey indicates that the divide and conquer repair of aging damage approach has become mainstream.

Fightaging as usual highlights this momentous milestone in antiaging. The Hallmarks of Aging is essentially a more mild-mannered and conservative restatement of the SENS approach to aging - written after more than ten years of advocacy and publication and persuasion within the scientific community by SENS supporters. To my eyes, the appearance of such things shows that SENS is winning the battle of ideas within the scientific community, and it is only a matter of time before it and similar repair-based efforts aimed at human rejuvenation dominate the field.



Hallmarks of Aging:

http://www.ff.ul.pt/FCT/EXPL/NEU-BEN/0241/2013/19.pdf

williatw
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Re: Factor X have we finally found the fountain of Youth?

Post by williatw »

Scientist: Tiny robots can find and kill diseases


http://www.myfoxdc.com/story/23788311/s ... z2ikjpigVi



Microscopic robots may soon be detecting and even preventing diseases instantly at doctors' offices across the nation, eliminating the need for multiple tests or treatment plans.

It may sound like science fiction, but one of the nation's top nanotechnology scientists said it could be only four or five years away.
"I think it's coming pretty soon," said Dr. Shree Singh, the director of the Center for NanoBiotechnology Research at Alabama State University. "In the near future, you will have some small nanomachines that will basically cure the disease before it even happens. Basically any kind of disease diagnosis or prevention can be done through nanobiotechnology."



Fat chance, at least that soon in IMHO, but you never know.

Schneibster
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Re: Factor X have we finally found the fountain of Youth?

Post by Schneibster »

williatw wrote:Fat chance, at least that soon in IMHO, but you never know.
Only if you have the money. It will be "experimental" and insurance won't pay.
We need a directorate of science, and we need it to be voted on only by scientists. You don't get to vote on reality. Get over it. Elected officials that deny the findings of the Science Directorate are subject to immediate impeachment for incompetence.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Post by williatw »

Bioengineer: the heart is one of the easiest organs to bioprint, we'll do it in a decade

http://www.wired.co.uk/news/archive/201 ... hole-heart


A team of cardiovascular scientists has announced it will be able to 3D print a whole heart from the recipients' own cells within a decade.

"America put a man on the Moon in less than a decade. I said a full decade to provide some wiggle room," Stuart K Williams told Wired.co.uk.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Post by williatw »

Anti-ageing compound set for human trials after turning clock back for mice

New South Wales professor in US rolled back the key indicators of ageing to make two-year-old mice appear six months old

http://www.theguardian.com/science/2013 ... man-trials


Australian and US researchers hope an anti-ageing compound could be trialled on humans as early as next year, following a key breakthrough that saw the ageing process reversed in mice.

The study, involving Harvard University and the University of NSW, discovered a way of restoring the efficiency of cells, completely reversing the ageing process in muscles.

Two-year-old mice were given a compound over a week, moving back the key indicators of ageing to that of a six-month-old mouse. Researchers said this was the equivalent of making a 60-year-old person feel like a 20-year-old.

...Turner said a “magic pill” that reverses ageing is several years away, partially due to the cost of the compound, which would be about $50,000 a day for a human.

But trials are expected to commence as soon as next year, with researchers confident that side-effects will be minimal due to the fact the compound is naturally occurring.

hanelyp
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Re: Factor X have we finally found the fountain of Youth?

Post by hanelyp »

Looks like 2 things are needed for this anti-aging compound:
- less expensive manufacture.
- long term animal testing. The drug turned back signs of age they tested for, but what is the total effect on healthy longevity? What factors of aging weren't tested for, and how do they express themselves? What side effects show up?
The daylight is uncomfortably bright for eyes so long in the dark.

GIThruster
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Re: Factor X have we finally found the fountain of Youth?

Post by GIThruster »

Yes, the testing will go for years if this is as successful as it appears. There are plenty of things to go wrong, but this is a ginormous step past the anti-aging tech of the early 90's. I wrote a thesis on anti-aging back in 93, and no one guessed that a reverse-aging claim would ever be made. In fact, the anti-aging guru's at that time said that was just fantasy. And yet, here it is. . .

There was a series pilot for a post-apocalyptic anti-aging culture back then, was great fun but never went into a series. Skip the first 10 minutes as it's all trailers.

https://www.youtube.com/watch?v=VKPSMCc0_WI
"Courage is not just a virtue, but the form of every virtue at the testing point." C. S. Lewis

williatw
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Re: Factor X have we finally found the fountain of Youth?

Post by williatw »

The target of action of the cell's mitochondria seem similar to this:

http://www.youtube.com/watch?v=etN_eulLO1I

You may recall the Russian Scientist Vladimir Skulachev claimed a few years back to be working on an anti-ageing pill. It also targeted the cell mitochondria. It has progressed to the point that eye drops called "Visomitin" are being sold in Russia, officially for "dry eye", wisely not claiming officially anti-ageing as such.


http://www.youtube.com/user/SkulachevIons?feature=watch


http://prixgalienrussia.com/en/skq-mito ... nnyiy-ant/

williatw
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Re: Factor X have we finally found the fountain of Youth?

Post by williatw »

The first 3D printed organ -- a liver -- is expected in 2014
Printed tissue could vastly improve drug testing

http://www.computerworld.com/s/article/ ... ed_in_2014

Computerworld - Approximately 18 people die every day waiting for an organ transplant. But that may change someday sooner than you think -- thanks to 3D printing.

Advances in the 3D printing of human tissue have moved fast enough that San Diego-based bio-printing company Organovo now expects to unveil the world's first printed organ -- a human liver -- next year.


Like other forms of 3D printing, bio-printing lays down layer after layer of material -- in this case, live cells -- to form a solid physical entity -- in this case, human tissue. The major stumbling block in creating tissue continues to be manufacturing the vascular system needed to provide it with life-sustaining oxygen and nutrients.

Living cells may literally die before the tissue gets off the printer table.

Organovo, however, said it has overcome that vascular issue to a degree. "We have achieved thicknesses of greater than 500 microns, and have maintained liver tissue in a fully functional state with native phenotypic behavior for at least 40 days," said Mike Renard, Organovo's executive vice president of commercial operations.

ladajo
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Re: Factor X have we finally found the fountain of Youth?

Post by ladajo »

So how do they plan to integrate it in a live body? Graft to exisiting tissue? What about the vascular system then?

I am certainly no biologist. Any one have any thoughts?
The development of atomic power, though it could confer unimaginable blessings on mankind, is something that is dreaded by the owners of coal mines and oil wells. (Hazlitt)
What I want to do is to look up C. . . . I call him the Forgotten Man. (Sumner)

mvanwink5
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Re: Factor X have we finally found the fountain of Youth?

Post by mvanwink5 »

The life of an organ is its stem cells. In the intestines these stem cells completely replace the lining in six weeks. Stem cell location for intestines is in the crypts and other organs (includes the brain), have a similar structure for the location of their stem cells. I don't know about muscles (smooth or skeletal). So, it is not as simple as printing cells (of course).
Counting the days to commercial fusion. It is not that long now.

williatw
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Re: Factor X have we finally found the fountain of Youth?

Post by williatw »

ladajo wrote:So how do they plan to integrate it in a live body? Graft to exisiting tissue? What about the vascular system then?

I am certainly no biologist. Any one have any thoughts?
So how would implanting a lab-grown organ made from your own cultivated stem cells be any different than implanting a transplanted organ from another person? Other than no risk of rejection, and the printed organ could be tailor made to replace your original organ.

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